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The combination of all these synthesis effects, occurring simultaneously through overlapping pathways, produces the skin quality improvements that clinical trials document
ACS Nano 17 , 1068910700 (2023)
Thus, the transition from crystal deposition to acute inflammation can be conceptualized as a two-hit process: First hit: MSU crystal deposition on cartilage surfaces activates synovial fibroblasts to release CCL2/MCP-1, recruiting monocytes and establishing subclinical inflammation
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