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In our study, FOXO4-DRI selectively induced apoptosis in senescent keloid fibroblasts by promoting the relocation of p53-pS15 from the nucleus to the cytoplasm, exhibiting similar clearance efficiency to that in normal skin fibroblasts
Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: Post-hoc analysis of an open-label, randomised, phase 3 trial
When used under medical supervision, tirzepatide not only supports weight lossit can also help reduce inflammation, improve metabolic health, and lower your risk of weight-related conditions like high blood pressure, insulin resistance, and cardiovascular disease
Clinical Trial Evidence and Findings in Female Participants Phase 2 trial data (Jastreboff et al., NEJM, 2023) showed dose-dependent weight reduction and metabolic improvements, but sex-disaggregated results were not published, so female-specific efficacy cannot yet be confirmed
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