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[5] The authors concluded that survodutide is generally tolerable in people with compensated or decompensated cirrhosis, does not require pharmacokinetic-based dose adjustment for cirrhosis, and may improve liver-related non-invasive tests supporting further investigation for MASH-related cirrhosis while remaining early-stage, small-sample, open-label evidence

Protein-sulfenic and glutathione sulfenic acids result from reaction with endogenously produced ROS or RNS but usually these species are rapidly transformed in prot-SSG (GSSR) or GSSG as more stable derivatives

Overall, this network-based analysis highlights interconnected metabolic and gene regulatory pathways that may contribute to ASD-associated metabolic dysregulation and offers a systems-level framework for prioritizing pathways for future mechanistic and validation studies

Schinkel, A