Through its deacetylase activity, the NAD + -dependent deacetylase sirtuin-1 (SIRT1) meticulously regulates a variety of substrates, such as histone and non-histone proteins, thereby producing significant effects on metabolic homeostasis, apoptosis regulation, inflammatory responses, attenuation of oxidative stress, and even the aging process (Tanno et al., 2007
It occurs at the level of gene transcription [11, 12], epigenetic regulation [13,14,15], post-translational modifications of core and accessory cell death machinery components [16,17,18], organelle-specific mechanisms [19], and organelle crosstalk [20, 21]
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Bertholet-Thomas A, Bacchetta J, Tasic V, Cochat P (2014) Nephropathic cystinosisa gap between developing and developed nations