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When present, side effects are typically mild and transient, potentially including slight drowsiness if administered too early (easily resolved by timing adjustment), mild headaches during initial adaptation in some individuals (usually resolving within days), temporary vivid dreams as sleep architecture normalizes, or rare reports of mild dizziness upon waking in sensitive individuals

This observation is consistent with a previous report demonstrating that long-term HFD consumption impaired liver regeneration in C57BL/6 mice through suppression of NF-B activation 44

Common doses are 200 to 500 micrograms once or twice a day, for 2 to 6 weeks

These findings suggest that nanocarrier-based chemotherapy can potentiate immune checkpoint inhibition by normalizing the TME, providing a mechanistic rationale for clinical translation (43)