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This reaction converts the reduced form of glutathione (GSH) into oxidized glutathione (GSSG), which is then reduced back to GSH by glutathione reductase (GR), using electrons from NADPH (Dringen and Arend, 2025)

doi: 10.3390/ijms23084181 218 PhuaJ.WengL.LingL.EgiM.LimC.-M.DivatiaJ

Indeed, redox modulation of ATG could impinge several fields interconnected with bioenergetics and metabolic adaptations to different stimuli

By restoring systemic glutathione levels, patients can improve their cellular redox buffer, potentially increasing their tolerance for daily activities and reducing the severity of exertion-induced crashes