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There is early evidence that creatine supplementation may improve memory, processing speed and other general facets of cognition
MOTS-C offers the most separate mitochondrial research angle but the weakest human treatment evidence
Not all possible drug interactions are listed here
However, from clinical studies alone, it is difficult to know how much of the benefit is due to direct effects in the joint and how much may be explained by weight loss or broader metabolic changes. That is why we wanted to address a basic mechanistic question first: whether GLP-1 is actually present in the joint environment
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