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Effectiveness in the treatment of diabetes and obesity In type 2 diabetes, GLP-1 receptor agonists are used to improve glycaemic control (often in combination with other medicines) and frequently result in weight loss
The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis
HIF-1 directly interacts with HREs in the promoter regions of genes encoding glycolytic enzymes, increasing the expression of key enzymes such as M2 pyruvate kinase (PKM2) [32], aldolase A [33], enolase (ENO) [33] and lactate dehydrogenase A [33]
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