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This analysis was a prespecified secondary analysis of the SUMMIT Trial, which showed that the long-acting glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist tirzepatide decreased risk of cardiovascular death or worsening heart failure (HF) in patients with (HFpEF). As it pertains to sex, the investigators noted that women outnumber men with HFpEF, and there are sexual dimorphisms in the relationships between body fat and pathophysiology in HFpEF that could influence response to tirzepatide. In the SUMMIT trial, the investigators analyzed 731 patients (338 men, 393 women) with class II-IV HFpEF and BMI of 30 kg/m 2 or greater
It typically peaks 24 to 72 hours after injection and gradually improves as the body adjusts
Both tirzepatide and semaglutide have shown promising results for weight loss and diabetes, but their long-term safety is still being studied
Melbourne bodybuilder Aaron Curtis says he does not use any drugs for weight loss, but he also told triple j Hack that at least three of his non-bodybuilding clients at his gym do
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