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9).195, 196 Prostaglandins E and F stimulate CRH release from cultured human placental cells, and CRH stimulates prostaglandin release from amnion and chorion cells.196, 197, 198 More specifically, CRH appears to up-regulate prostaglandin synthase (PGHS), the activity of which stimulates the production of primary prostaglandins from arachidonic acid, and CRH down-regulates prostaglandin dehydrogenase (PGDH), which metabolizes prostaglandins in the fetal membranes.197, 199 Similarly, oxytocin stimulates placental cells to secrete CRH, which then increases the release of immunoreactive oxytocin from placental cells.200, 201 These observations suggest that placental CRH, prostaglandins, and oxytocin interact in a feed-forward regulatory loop that promotes labor