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NICE guidance on bipolar disorder and physical health in serious mental illness emphasises the importance of managing cardiometabolic risk factors
This superior efficacy helped it achieve global sales of ~US$16.4bn in 2024 (Mounjaro ~US$11.5bn and Zepbound ~US$4.9bn), rivalling semaglutide and completely overshadowing the sales of historical GLP-1s, such as exenatide, liraglutide and dulaglutide [FIGURE TWO]
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Studies show that patients on slower ramp-ups experience nausea rates of 2030%, while those jumping to higher doses too quickly report nausea in 4050% of cases
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