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An exploratory mediation analysis of stroke outcomes in the REWIND CVOT, in which dulaglutide reduced systolic blood pressure (SBP) by a mean of 1.7 mmHg compared to placebo, found that the blood pressure reduction caused by dulaglutide accounts for around 14% of its effect on stroke risk [21]
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Cell 21 , 11711178 (2011)
Thus, we can argue that one important role that the peroxisome plays is to extract deupleted protons from solution and deliver them to the mitochondria, and, ultimately, to the ATPase pumps, in the form of H 2 O 2
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