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Meta-analyses of randomized trials corroborate these findings: one large review of 27 RCTs reported no significant difference in suicidality between GLP-1 RAs and placebo (RR 0.76) [48], while another meta-analysis including 25 trials similarly showed no association across multiple subgroups and endpoints (RR 0.84) [49]
In addition, energy expenditure is decreased following diet-induced weight loss, with the implication that reduced food intake would need to be maintained in the long-term [12]
Its significant function in metabolism has made L-Carnitine a well-known component in the weight-loss realm
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