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All patients should reduce premeal insulin by 50% to lessen the risk of insulin-induced hypoglycemia, monitor blood glucose frequently, and contact their health care provider if symptoms of nausea and/or hypoglycemia are severe or unusually persistent and when the dosage of pramlintide or insulin is changed
Serum levels drop roughly 60% between age 20 and age 60, which is the core rationale for exogenous replacement
E., Shalem, O
(PubMed) Jones W, Li X, Qu ZC, Perriott L, Whitesell RR, May JM
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