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The Pharmacology of Liraglutide and Semaglutide Liraglutide and semaglutide are both long-acting GLP-1RAs that, despite differing administration intervals and doses, have pharmacodynamic (PD) effects for 24 h/day (124, 125)

Figure from Rossing et al NDT 2023 Primary Outcome This was a composite of time of first occurrence of: Onset of kidney failure (persistent eGFR 28 days or initiation of long-term KRT, kidney transplantation) Persistent 50% reduction in eGFR from baseline Death from kidney or CV causes Secondary Outcomes Confirmatory secondary outcomes were analyzed hierarchically

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