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Bipolar affective disorder (BPAD) is associated with malfunctioning oxidative systems, whereas antidepressants appear to protect oxidative systems and protect nerve cells from harm caused by oxidative damage

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Notably, thyroid hormones may facilitate augmented carnitine synthesis in the liver by increasing -butyrobetaine hydroxylase (BBD) activity and gene expression, which may constitute a feedback regulatory loop between thyroid hormones and carnitine [80]