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A purplish-red solid product was obtained
The importance of W33 in small-molecule activation of GLP-1R was curious since it is located on the extracellular domain (ECD), distal from the transmembrane domains and connecting loops directly involved in peptide-induced GPCR activation ( 20, 32 )
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Published data on lobe differences in endogenous and induced enzymes is scarce, although many researchers suspect there may be important lobe differences based on differential blood flow (Wilson and Hiley 1983) and the observation of lobe differences in toxic responses
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