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The dynamics of switching once are fundamentally different from switching back and forth every few months
When researchers delete the GLP-1 receptors from the brains of mice, the drug loses its appetite-suppressing effects, says Krashes
That said, you may want to let it cool before drinking or opting for cold, grab-and-go varieties
Importantly, there is evidence that the effects of both medications varies by disease stage [47, 48], although results from real-world studies of SGLT2is support their effectiveness on cardiovascular and kidney outcomes in broader populations [49, 50]
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