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Metabolomic assessment reveals alteration in polyols and branched chain amino acids associated with present and future renal impairment in a discovery cohort of 637 persons with type 1 diabetes
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This neuroprotective mechanism was found to occur in concert with a suppression of proinflammatory cytokines released from the activated microglia, suggesting an anti-inflammatory mechanism upstream from the neurodegeneration of dopaminergic neurons
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
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