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The mechanism involves: Cholinergic antagonism -- cortistatin reduces cortical arousal by antagonizing acetylcholine-mediated excitation, effectively dampening the wake-promoting cholinergic system that maintains cortical desynchronization during wakefulness EEG synchronization -- the transition from wakefulness to SWS is characterized by increasingly synchronized, high-amplitude delta waves on EEG

There is no clear evidence that AOD-9604 directly activates 3-adrenergic receptors

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Unlike most antioxidants, glutathione can be made in the human liver