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4.2 Enhancing CAR T-Cell safety with peptide-based approach A recent Phase 1 first-in-human trial exploring PSCA-CAR T cell therapy has shown promising bioactivity and initial signs of clinical success

The same set of experiments was conducted for GSSSG-pretreated HGF as a control and results indicated a nearly negligible preventive-effect on HGF nitration (Figure 2c), consistent with the earlier observation that GSSSG treatment barely enhanced HGF-c-met interaction before and after exposure to peroxynitrite (see again Figure 1e, bars 47 and bars 47 )

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Another study further tests the correlation between GSH depletion and patients with MCI and results in a similar conclusion (Lin and Lane, 2021)