![step 11 semaglutide trial shows 16% weight loss in Asian adults with BMI > 25 | Michael Weintraub, MD posted on the topic PDF] Effect of Subcutaneous Semaglutide](https://media.licdn.com/dms/image/v2/D4E10AQGftZ44Nsi4wQ/image-shrink_800/B4EZjCJW5UGYAg-/0/1755603890858?e=2147483647&v=beta&t=XPLYSjdG4HCrg25FYnluHfXrrJb6mNLjewhQwyDH4Hg)
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The key is working with providers who use certified compounding pharmacies, not fly-by-night operations mixing medications in questionable facilities
![step 11 semaglutide trial shows 16% weight loss in Asian adults with BMI > 25 | Michael Weintraub, MD posted on the topic PDF] Effect of Subcutaneous Semaglutide](https://figures.semanticscholar.org/d41b60396b3e16265d197d5dae49fdcd493f4490/5-Table1-1.png)
High doses of iron may deplete glutathione levels in the body
![step 11 semaglutide trial shows 16% weight loss in Asian adults with BMI > 25 | Michael Weintraub, MD posted on the topic PDF] Effect of Subcutaneous Semaglutide](https://www.frontiersin.org/files/Articles/1398059/xml-images/fnut-11-1398059-g001.webp)
For years, the idea of activating glucagon receptors for weight loss seemed counterintuitive since glucagon raises blood sugar
![step 11 semaglutide trial shows 16% weight loss in Asian adults with BMI > 25 | Michael Weintraub, MD posted on the topic PDF] Effect of Subcutaneous Semaglutide](https://substackcdn.com/image/fetch/$s_!cwg2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0c56b856-b4cb-4685-9469-6806f786d81e_3721x1617.jpeg)
However, during homeostasis of in the presence of anti-inflammatory cytokines, this is shifted and astrocytes export iron, which can be used by microglia and OLs to drive remyelination and repair
![step 11 semaglutide trial shows 16% weight loss in Asian adults with BMI > 25 | Michael Weintraub, MD posted on the topic PDF] Effect of Subcutaneous Semaglutide](https://www.nejm.org/cms/asset/8e136483-fbab-45d0-b509-e1246f2168e3/nejmoa2032183_f1.jpg)
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