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But B12 shots themselves arent associated with weight loss

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Tirzepatide represents a dual agonist, activating both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, which may explain its particularly robust weight loss effects

At the same time as the UCL study was released, another study of a new drug, retatrutide, found that it could be even more effective with participants losing 24% of their body weight over 48 weeks, partly because it has an impact on metabolism as well as appetite