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In SURMOUNT 1, tirzepatide induced a mean BW reduction of 15.0%, 19.5% and 20.9% with 5 mg, 10 mg and 15 mg, respectively compared to 3.1% obtained with placebo at 72 weeks 34
A second molecule of NADPH is generated in the next step of the pathway, catalyzed by another enzyme, 6-phosphogluconate dehydrogenase (6PGD)
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