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Given that female mice typically possess a higher baseline fat mass due to estrogen-driven adiposity (36), the increased energy demand during semaglutide treatment is likely met through enhanced fat oxidation rather than muscle catabolism (37), thereby preserving lean tissue

The widespread interest in GLP-1 receptor agonists for weight loss, particularly amid drug shortages, has renewed clinical and regulatory attention to their safety profile, yet the clinical profile of acute exposures remains poorly understood, wrote first author Jordan Miller, a researcher with The University of Texas at San Antonio, and colleagues

Eli Lilly), an oral small-molecule GLP-1 receptor agonist, highlighting continued innovation in this therapeutic class

Contrave contains two ingredients: naltrexone and bupropion, and is used for long-term weight management