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In agreement with this hypothesis, both the ascorbate- deficient mutant vtc2-4 (which contains only 30% of the wild-type ascorbate) and the vtc2-4 dhar quadruple mutant showed comparable ascorbate accumulation in response to high light
Both Mounjaro and Zepbound contain the GLP-1 agonist tirzepatide
The involvement of GLP-1 in PD can be simplified to the activation of the MAPK/extracellular signal-regulated kinase 1/2 (ERK) pathway, which has an important role in synaptic plasticity, and the PI3K/Akt pathway signaled by GLP-1 receptor stimulation and the subsequent increase in cAMP and PKA and PI3K activation [73]
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