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Why your body sometimes struggles to absorb vitamin B12: 4 Stomach or intestinal disorders, e.g., gastritis, Crohns disease Stomach surgeries that alter the points of absorption Medications such as gastric acid blockers or metformin When your needs increase Sometimes your body simply needs more: during pregnancy and breastfeeding 5 during growth phases 6 with high alcohol consumption 7 With age As we age, our bodies produce less stomach acid, which reduces our ability to absorb vitamin B12

That is a different mechanism from tirzepatide, which acts on GLP-1 and GIP receptors to reduce appetite signaling and improve insulin sensitivity

Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, et al

doi: 10.1016/S0140-6736(00)02490-9 100 WangFLiCLiSCuiLZhaoJLiaoL