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Until such studies are conducted, the combination remains investigational and should be approached with appropriate caution, written informed consent, and consideration of FDA MedWatch reporting for any adverse events that occur with off-label combination use
The weight gain with IGF-1 therapy is primarily due to muscle growth not water retention
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254,255 Keap1/Nrf2/ARE signaling pathways As mentioned, the NF-B, MAPK, and JAK-STAT (signal transducers and activators of transcription) signaling pathways are involved in the development of inflammation
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