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The plateau-breaking potential is one of the primary reasons clinicians combine these compounds
They start with 510 shots over a few weeks, then gradually space them farther apart, sometimes by months
This complete absence of tolerability-driven discontinuations represents a remarkable safety finding and indicates that even when mild side effects occurred, they were sufficiently manageable that participants chose to continue treatment
The clinical development program was discontinued due to insufficient weight loss efficacy rather than safety concerns
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