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Although high caffeine intake (greater than 300 milligrams per day) does increase the amount of calcium excreted in the urine, and the risk for osteoporosis-related fractures was significant among women consuming 4 or more cups of coffee per day, this increase in risk was seen only in those with calcium intakes less than 700 millligrams per day
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GHK-Cu's natural occurrence in human plasma suggests better tolerance for extended therapy, though both appear safe when used appropriately
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