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The imputation model was a linear regression of the endpoint with gender as factor and baseline value of the endpoint, timing and the value of last available observation on study (LAO-OS) of the endpoint as covariates, imputed by treatment status
when considering complex experimental designs involving compounds like Retatrutide and Tirzepatide
In the interim, NICE-approved options for weight management in adults with obesity include: Orlistat (available on NHS prescription) Semaglutide 2.4 mg (Wegovy) , recommended by NICE in 2023 for use in specific patient groups (NICE technology appraisal TA875) Tirzepatide (Mounjaro) , which received NICE approval in 2024 for obesity management (NICE technology appraisal TA1026) [18] Patients seeking advice about weight management or blood pressure control should be directed to their GP in the first instance, who can assess eligibility for currently approved treatments and refer to specialist services where appropriate
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