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Thus, current 3D cell culture systems are broadly classified into scaffold-based and scaffold-free, depending on whether cells grow with or without the support of a physical structure [245]

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These factors are crucial in the premature clearance of erythrocytes from circulation, a mechanism similar to that in HbE/-thalassemia [414]

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Using the Cox proportional hazard model, the following factors were associated with the development of AH during follow up: On Medicaid (aHR:3.6, 95%CI: 2.4-5.5, compared to employer-based) or no health insurance (aHR:2.4, 95%CI:1.5 3.7, compared to employer-based), positive AUDIT-C score at baseline (aHR:11.63, 95%CI:8.5-16), and age (aHR:1.69, 95%CI:0.97-2.94 for 45-65 years old compared to the 18-35 age group)

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