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In the SURMOUNT-1 trial, participants on tirzepatide 15 mg lost an average of approximately 22.5 percent of body weight over 72 weeks, outcomes that begin to approach those seen with bariatric surgery

It is not medical advice and is not a recommendation to use any substance

Additionally, the same detox and metabolism triggered by the above can also cause a partial histamine breakdown and trapping of methylhistamine which can aggravate all the Sx you mention as well

GLP-1 vs GIP vs Glucagon: Understanding the Differences GLP-1, GIP and glucagon are three hormones that play important roles in metabolism, energy balance and glucose regulation