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In a study published in December 2018 in Nutrients , 30 adults with no chronic disease experienced severe diarrhea and GI symptoms such as bloating and nausea after ingesting 0.5 grams of allulose per kilogram of body weight in a single serving, but they had no symptoms at lesser amounts
Unlike fulllength hGH, AOD9604 does not meaningfully elevate IGF1 levels or worsen glucose tolerance, making its tolerability indistinguishable from placebo in human trials [2] [3]
The phase 2 trial found that starting at 2mg rather than 4mg significantly reduced nausea rates during escalation, validating the conservative titration approach
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