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The enzyme plays a crucial role in the production of red blood cells, the functioning of the nervous system, and the synthesis of DNA

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In addition, mitochondria modulate intracellular calcium homeostasis and immune regulatory pathways (420, 421), which means these pathways may too be compromised in ME/CFS

The CYP1A2 gene has a well-studied polymorphism at position rs762551 that creates three distinct categories of caffeine metabolism: [2] The Three Metabolizer Types AA genotype (fast metabolizers): These individuals rapidly clear caffeine and typically experience its benefits without pronounced side effects