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Activation of large-conductance (BK Ca ) and small-conductance (K Ca ) K + channels, as well as ATP-sensitive K + (K ATP ) channels, induces K + efflux, reducing Ca 2+ entry through voltage-gated calcium channels (VGCCs), leading to pericyte hyperpolarization and increased CBF [93]
Patients should use a standardized reconstitution calculator and verify their math with their pharmacist before drawing the first dose from a new vial [14]
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It is worth noting that whilst some improvement may be rapid, complete resolution of symptomsparticularly neurological onescan take months of regular treatment
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