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In endothelial cell models, BPC-157 enhanced ERK1/2 phosphorylation in a dose-dependent manner, increasing cellular proliferation, migration, and vascular tube formation via downstream transcription factors c-Fos, c-Jun, and EGR-1
This profile makes BPC-157 more difficult to interpret than peptides whose experimental readouts are directly linked to receptor occupancy or a defined receptor-to-pathway cascade
doi: 10.1016/j.ahj.2007.02.029 103
NNMT activity increases with age, obesity, and metabolic dysfunction
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