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Side effects with survodutide were in line with those expected for GLP-1 RAs and were the principal cause of discontinuation 24.6% in the survodutide groups versus 3.9% with placebo

SURMOUNT-5 reported a mean weight loss of -20.2% on tirzepatide versus -13.7% on semaglutide over 72 weeks in 751 adults with obesity

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