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A total of 577 patients were randomly assigned (1:1:1) to receive once-weekly dulaglutide (1.5 mg), once-weekly dulaglutide (0.75 mg), or daily insulin glargine as basal therapy, all in combination with insulin lispro, for 52 weeks
[DOI] [PubMed] Clairembault T, Kamphuis W, Leclair-Visonneau L, Rolli-Derkinderen M, Coron E, Neunlist M, et al
This danger is blunted or even absent, however, when the drug is given orally
The clinical significance of this effect in humans on pharmacological doses of tirzepatide is theoretical, but the mechanistic logic is sound
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