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It's estimated that between 10 percent and 30 percent of people older than 50 produce too little stomach acid to release B12 from its carrier protein in foods
Nonetheless, the pharmacological activation of the GLP-1R is clinically beneficial (179), offering an improved glycaemic control with lower cardiovascular morbidity and without the risk of hypoglycaemia associated with some current anti diabetic drugs (173)
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The selectivity data are primarily from Raun et al.'s rat work
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