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Among them, the thiol group (-SH) on the cysteine residue is the key active site through which glutathione performs antioxidant, detoxification, and other functions

We believe maintaining the glutathione-to-iron ratio is very important, because if you have too little glutathione, then iron becomes very reactive, and if you have too much glutathione, the iron will not be usable. Their experiments determined that SLC25A39 carries a unique iron signature on its surface as part of the glutathione sensing mechanism

D., and Fink, W

Although the discovery and validation of these biomarkers demand extensive collaborative research, their potential impact on diagnostics and therapy is significant