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In 1973, John Brown discovered the glucose-dependent insulinotropic polypeptide (GIP) employing peptide purification and protein sequencing, it was shown to have an incretin effect, increasing Insulin release triggered by glucose intake after oral administration [11]
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MT-II is a cyclic heptapeptide broadly activating MC1R, MC3R, and MC4R , simultaneously producing melanogenesis alongside central pro-sexual, pro-erectile, and anorectic effects through hypothalamic MC3R/MC4R activation, Cyclisation of the -MSH pharmacophore core is the primary structural determinant of this receptor subtype selectivity shift
