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What is the difference in dosing
When activated alongside GLP-1, glucagon receptor stimulation drives thermogenesis (heat production from calorie burning), accelerates fatty acid oxidation, and increases resting metabolic rate
Metformin typically causes gastrointestinal symptoms like nausea or loose stools, while semaglutide may produce mild nausea during dose escalation
The April 2024 Phase 3 readout in type 2 diabetes reported a 14.2% mean body-weight reduction at 68 weeks for CagriSema 2.4mg/2.4mg versus 10.2% for semaglutide 2.4mg alone [4]
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