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Whether this reflects a shift from GHD1 to GDH2 isoform [28] is not known but, if so, this pushing effect of reduced pH effect could be additive with the above pulling effect of a reduced TCA pool (Figure 2)

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Animal studies have shown that when beta-3 adrenergic receptors were genetically removed, chronic AOD-9604 treatment produced no changes in weight or lipolysis, confirming the importance of this pathway

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