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Women of childbearing age should discuss effective contraception before starting treatment, and should inform their doctor promptly if they become pregnant
Signs of a potential allergic response include: Widespread rash or hives appearing beyond the injection site Intense itching affecting multiple body areas Swelling of the face, lips, tongue, or throat (angioedema) Skin reactions accompanied by difficulty breathing or swallowing These symptoms may indicate hypersensitivity and warrant prompt medical evaluation
In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision
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