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When taken for a long term, it is associated with a decrease in zinc level and also causes toxicity to the liver
Berberine supplementation did not cause changes in kidney or liver function tests in patients
The overall experience exceeded expectations
In a diabetes MRI substudy, liver fat fell up to 47% at 15 mg versus about 11% on insulin. In biopsy-confirmed fatty-liver disease with fibrosis, a large share of participants on 15 mg had disease resolution versus a small share on placebo. These are not microdose data
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