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[26], who engineered hMSC to overexpress Ex-4 (hMSC-E4) using lentiviral transduction
However, CIs for many sensitivity analyses crossed the null (OR = 1), particularly in MR-Egger, which is known to have lower statistical power due to its reliance on stronger assumptions (e.g., Instrument Strength Independent of Direct Effect)
The adjustment is to use fat as the dietary lever you reduce when appetite is already suppressed, rather than forcing fat intake to hit macro targets
Compared to Ozempic, which only targets GLP-1, these medicines may provide broader and more powerful results
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