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Whilst great advancements have been made over the last century with regard to understanding the regulation of metabolic homeostasis which has yielded new therapeutic options for diseases such as T2D, it is unlikely that highly desirable more efficacious treatments will be developed for metabolic disorders until the complex systemic regulation of metabolic homeostasis becomes more intricately understood

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However, diabetes and obesity are both metabolic disorders, and there is a growing recognition that obesity, diabetes, and arrhythmias (especially AF) are closely intertwined epidemics

Compare With Alternatives Several GLP-1based options may be considered if goals or preferences differ