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(29) Female mice were fed a high-fat diet to induce obesity and type 2 diabetes before being treated with semaglutide (10 nmol/kg) or insulin (0.5 U/kg) for up to 28 days

This is, to our knowledge, the first description of a three-way contact between an endosomal GPCR, the ERMCS tether VAPB, and a PKA-RI-recruiting AKAP, which uncovers the assembly of a GLP-1R-induced ERMCS-localised PKA biomolecular condensate to control mitochondrial turnover and function

Front Cell Dev Biol 9:267 Johnson BZ, Stevenson AW, Prle CM, Fear MW, Wood FM (2020) The role of IL-6 in skin fibrosis and cutaneous wound healing

GLP-1R expression on cells is low