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Why Fat Loss From GLP-1 Medications Help the Heart Clinical trials consistently show that Semaglutide leads to 10-15% total body weight loss in many individuals, even without diabetes

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The claim: "If you stay on Wegovy for 12 to 18 months, your body will adapt to the new lower weight and defend it naturally after you stop." Why it is wrong: Weight set point is regulated by the hypothalamus based on long-term energy stores (primarily leptin signaling from adipocytes)

The results were announced today at the annual meeting of the American Diabetes Association and published in the New England Journal of Medicine